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Patrick T Gunning Selected Research

AES-135

1/2019Identification and Characterization of AES-135, a Hydroxamic Acid-Based HDAC Inhibitor That Prolongs Survival in an Orthotopic Mouse Model of Pancreatic Cancer.

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Patrick T Gunning Research Topics

Disease

47Neoplasms (Cancer)
12/2023 - 08/2009
5Leukemia
07/2021 - 02/2011
5Multiple Myeloma
09/2013 - 02/2011
4Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
12/2023 - 02/2012
3Brain Neoplasms (Brain Tumor)
01/2022 - 02/2011
3Hematologic Neoplasms (Hematological Malignancy)
01/2020 - 08/2011
3BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia)
01/2017 - 03/2015
2Lymphoma (Lymphomas)
10/2022 - 02/2011
2Neoplasm Metastasis (Metastasis)
01/2022 - 05/2016
2Pancreatic Neoplasms (Pancreatic Cancer)
01/2019 - 01/2016
2Breast Neoplasms (Breast Cancer)
01/2016 - 06/2012
1Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker)
12/2023
1Central Nervous System Diseases (CNS Diseases)
01/2023
1Inflammation (Inflammations)
01/2023
1Psoriasis (Pustulosis Palmaris et Plantaris)
01/2023
1Cutaneous T-Cell Lymphoma (Lymphoma, T Cell, Cutaneous)
12/2022
1T-Cell Lymphoma (Lymphoma, T Cell)
10/2022
1Medulloblastoma
01/2022
1Immune System Diseases (Immune Disorders)
01/2022
1Schistosomiasis (Bilharziasis)
01/2022
1T-Cell Prolymphocytic Leukemia (Leukemia, T Cell, Chronic)
01/2021
1Peripheral T-Cell Lymphoma (Lymphoma, T Cell, Peripheral)
01/2020
1Carcinoma (Carcinomatosis)
10/2019
1Colonic Neoplasms (Colon Cancer)
05/2016
1Philadelphia Chromosome
03/2015
1Stomach Neoplasms (Stomach Cancer)
04/2014
1Glioblastoma (Glioblastoma Multiforme)
11/2013
1Mantle-Cell Lymphoma (Lymphoma, Mantle Cell)
01/2013
1Lung Neoplasms (Lung Cancer)
06/2012

Drug/Important Bio-Agent (IBA)

14Proteins (Proteins, Gene)FDA Link
01/2023 - 12/2009
13STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA
10/2019 - 12/2009
7Phosphotransferases (Kinase)IBA
12/2022 - 04/2014
6Transcription Factors (Transcription Factor)IBA
01/2020 - 12/2009
5Histone Deacetylase InhibitorsIBA
12/2023 - 01/2019
5Histone Deacetylases (Histone Deacetylase)IBA
01/2023 - 01/2019
3STAT5 Transcription FactorIBA
05/2020 - 02/2012
3Tyrosine Kinase InhibitorsIBA
01/2017 - 03/2015
3UbiquitinIBA
01/2016 - 01/2013
2Biomarkers (Surrogate Marker)IBA
12/2023 - 01/2016
2Histone Deacetylase 6IBA
01/2023 - 01/2022
2Protein Isoforms (Isoforms)IBA
01/2022 - 05/2016
2Tyrosine (L-Tyrosine)FDA Link
07/2021 - 01/2018
2Salicylic Acid (2 Hydroxybenzoic Acid)FDA LinkGeneric
11/2014 - 08/2009
2pevonedistatIBA
01/2014 - 08/2011
2purineIBA
09/2013 - 01/2011
2EnzymesIBA
03/2013 - 08/2011
2PhosphotyrosineIBA
08/2012 - 05/2010
2Peptides (Polypeptides)IBA
06/2012 - 03/2011
1HydrolasesIBA
12/2023
1MyogeninIBA
12/2023
1FRAX597IBA
12/2022
1Thalidomide (Thalomid)FDA Link
01/2022
1ProteomeIBA
01/2022
1Lenalidomide (CC 5013)FDA Link
01/2022
1Hydroxyurea (Hydrea)FDA LinkGeneric
07/2021
1RG7388IBA
01/2021
1Bendamustine HydrochlorideFDA Link
01/2021
1venetoclaxIBA
01/2021
1citarinostatIBA
09/2020
1ricolinostatIBA
09/2020
1Janus Kinase 2IBA
04/2020
1ruxolitinibIBA
01/2020
1Janus Kinase InhibitorsIBA
01/2020
1CholesterolIBA
01/2020
1Caveolin 1IBA
10/2019
1AES-135IBA
01/2019
17- O- (2,6- dideoxy- 2- fluorotalopyranosyl)daunomycinoneIBA
01/2019
1Hydroxamic Acids (Hydroxamic Acid)IBA
01/2019
1Drug CombinationsIBA
01/2017
1Cell Adhesion Molecule-1IBA
05/2016
1Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA
05/2016
1Small Interfering RNA (siRNA)IBA
05/2016
1CEACAM1 ProteinIBA
05/2016
1Carcinoembryonic AntigenIBA
05/2016
1NSC 74859IBA
04/2016
1Angiogenesis Inducing Agents (Angiogenesis Factor)IBA
04/2016
1Cystine (L-Cystine)IBA
01/2016
1Glutamic Acid (Glutamate)FDA Link
01/2016
1AntiportersIBA
01/2016
1BP-5-087IBA
03/2015
1Proto-Oncogene Proteins c-metIBA
04/2014
1ChromatinIBA
04/2014
1Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA
04/2014
1Mitogen-Activated Protein Kinase Kinases (MEKs)IBA
04/2014
1Proteasome InhibitorsIBA
01/2013
1Proteasome Endopeptidase Complex (Proteasome)IBA
01/2013
1SurvivinIBA
06/2012
1Focal Adhesion Protein-Tyrosine KinasesIBA
06/2012
1PaxillinIBA
06/2012
1immunoglobulin-binding factorsIBA
06/2012
1Macrophage Migration-Inhibitory FactorsIBA
06/2012
1Serine Proteinase Inhibitors (Serine Protease Inhibitors)IBA
06/2012
1BP-1-102IBA
06/2012
1Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)IBA
06/2012
1Cadherins (E-Cadherin)IBA
06/2012
1Cyclin D1IBA
06/2012
1Factor VIII (Coagulation Factor VIII)IBA
06/2012
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
06/2012
1Granulocyte Colony-Stimulating Factor (G-CSF)IBA
06/2012

Therapy/Procedure

11Therapeutics
10/2022 - 02/2012